Fiona and Gus must navigate the awkwardness of their quickie wedding but Fiona's plans to announce her marriage at a family dinner become unravelled when her co-worker overdoses.
Lip heads back home from college to find that the old neighbourhood is changing. Fiona balances her new job with a crush on her older boss.
Fiona is finally officially off house arrest. Lip starts his first day of work for Tommy but manual labour turns out to be much harder for Lip than he thought… and the brutal hazing from his co-workers certainly doesn't help.
The gentrification of Chicago's Back of the Yards neighbourhood continues as Frank enlists Carl to scare off potential investors who are buying up more property in the neighbourhood, while pleading with Sheila not to cave and sell her home.
Arriving at Lou's to pick up his six-figure insurance settlement, Frank's shocked to discover that he's already collected it. Meanwhile, Lip visits Amanda and her family at their luxurious house in Miami.
Fiona is thrown in to chaos by the return of Jimmy/Jack/Steve, but she must deal with an even larger crises first as Ian, in a full psychotic break, steals Mickey and Svetlana's baby and takes him along on a road trip... but Jimmy is relentless in his pursuit of Fiona.
As Ian begins to regain some of his senses, he's upset to find himself under a mandatory 72-hour psych hold.
When Lip and Fiona arrive to pick Ian up from the psych ward, Mickey is noticeably absent. Ian's doctor encourages them to get Ian on a regimen of pills, which proves to be difficult as Ian refuses to accept his bipolar diagnosis.
Frank goes to see his uptight doctor, Bianca, for a wound check-up, but Bianca is falling apart after receiving a grim cancer diagnosis.
Frank is having a ball with new sick friend Bianca, but when Bianca thinks Frank might be developing feelings for her, she kicks him to the curb.
A lot of new sexual tension exists between Fiona and Sean after their night at the diner. With Ian now in a military pre-trial facility, the gang must set off to visit him and to explain his condition to his attorneys.
Fiona reunites with Gus after he returns from his tour but is torn by the fact that her friendly feelings for Sean have turned into love. Down in Costa Rica, Frank has love struggles of his own while he works to keep Bianca happy in her dying days.