The team goes after a group of sleeper spies that have just been activated and race to stop a slew of assassinations.
A beautiful, naked amnesiac is found in Times Square covered in mysterious tattoos, including one bearing the name of FBI Agent Kurt Weller. Special Agent Weller and his team must decode the map of clues on Jane Doe's body in order to thwart a deadly terrorist attack.
The team unlocks a cryptic tattoo that points to an Air Force pilot with a painful past and a lethal agenda. Jane continues to search for clues to her identity and is haunted by flashes of a disturbing memory. Meanwhile, Weller thinks he might know Jane's true identity.
When an infamous crew of thieves almost pulls off the perfect jewel heist, one thief - with an identical Navy SEAL tattoo to Jane's - is captured at the scene of the crime. Meanwhile, Jane receives a visit, and an ambiguous warning, from the mysterious rugged man.
Patterson and her puzzle-expert boyfriend decode a tattoo clue that sends the team to the Centers for Disease Control (CDC). While at the CDC, the team discovers a hidden message on Jane's body that uncovers a plot that could have catastrophic global consequences.
After a hostage situation turns out to have international implications, the CIA and FBI find themselves racing against each other to apprehend the criminal. Carter expresses concern about Jane's trustworthiness, causing friction with Mayfair and testing Reade's loyalty.
When an assassination leads to a dangerous app that allows criminals to track government vehicles, the team must work with the app's creator to take it down. While Zapata struggles with a moral issue, Jane and Weller attempt to keep their relationship professional.
One of Jane's tattoos sends the team to a remote location where they find themselves face to face with a dangerous criminal in a case that puts the strained relationship of Jane and Weller to the test and threatens to expose Mayfair's secrets.
After a police officer is murdered, Patterson unlocks a tattoo that appears to have predicted his killing, leading the team to chase a violent clue trail to stop further attacks. Mayfair reveals secrets from her past to Weller, seriously testing their relationship.
Jane and Weller go undercover as a world-class assassin couple to prevent deadly information from getting into the wrong hands. Meanwhile, David embarks on a solo mission to win Patterson back, and Carter clashes with Mayfair over how to handle a dangerous individual.
Jane reels from a series of massive revelations about her tattoos and grapples with whether to trust Oscar. Meanwhile, a tattoo leads the team to a shocking discovery in the Black Sea.
After a disturbed Iraq War vet shoots up a military base, the team exposes a sinister plot. As Jane and Weller race to stop a single-minded scientist, Jane recalls her own mysterious military past and contemplates a new relationship with Oscar.
After a tip reveals there's a mole within the FBI's New York Office, the team must hunt for the operative while facing extreme scrutiny from Inspector Fischer. The team's secrets threaten to be exposed, and everyone is a potential suspect - but some have more to hide.
An anonymous tip leads the team to investigate an urgent Death Row case - ultimately sending Zapata undercover. After nearly getting caught during the mole hunt, Jane considers leaving the FBI.
After a painting featuring one of Jane's tattoos is heisted from a gallery, the team discovers Jane is the real target. Wanting to protect her team, Jane goes AWOL.
After an armoured truck is robbed, the team discovers that the stolen goods are chemical weapons and they must race to thwart a terrorist plot. Meanwhile, Jane grapples with a confusing memory of Weller - while growing even closer to Oscar.
After discovering a hidden message in the New York Times crossword, Patterson embarks on a tattoo scavenger hunt that leads her into danger. Meanwhile, Oscar finally tells Jane more about who she was, and Weller seeks his dad's opinion on who kidnapped Taylor Shaw.
To capture a dangerous international criminal, Jane and Weller are forced to collaborate with the only person he will meet: their former target Rich DotCom. Meanwhile, Jane must decide whether to risk hurting Weller by executing a morally questionable order from Oscar.
When a school shooting breaks out during the investigation of a tattoo, the team splits up to take down the shooter. Mayfair, meanwhile, copes with some issues from her past.
When a girl with a tattoo connection falls into Borden's care, he brings her case to the FBI team - but her ties to a terrorist organisation prove dangerous for all. Meanwhile, a conflicted Jane grows closer to Weller, and friendship blooms between Borden and Patterson.
The FBI is locked down when criminal hackers infiltrate the building, trapping the team inside SIOC. As they fight their way out, the close quarters force Mayfair, Zapata, Reade, and Sarah to confront personal conflicts.
After an abandoned baby is found with a tattoo identical to one of Jane's, the team races to piece together the child's identity and save dozens of infants. Meanwhile, a furious Jane confronts Oscar about he outcome of his secret missions.
Weller searches for the truth within a heart-breaking and confounding assertion. Jane reaches out to a former suspect for help with Oscar. The rest of the team, meanwhile, struggle to help a friend.